Ekspresi Glukosa Transporter-2 di Sel Beta Pankreas dan Sel Hepatosit Tikus yang Diinduksi Diabetes Mellitus

Diabetes Mellitus (DM) is an incurable disease that can be prevented clinically from worsening. This based on classification related to pancreatic damage in total or partial so the impact insulin production. Glucose transporter a protein glucose uptake outside cell into and provides important role body's homeostasis. transporter-2 (GLUT-2) found pancreas, liver, kidney. Parameters used are expression amount of GLUT-2 density β cells hepatocyte normal diabetic Rat. Used Wistar strain male white rats. An immunohistochemistry (IHC) staining technique was performed observe macbiophotonics image J program determine GLUT-2. marked brown nucleus surrounded by cytoplasm. The results showed increased with 25,447,052 decreased 5,074,544 Streptozotocin 50 mg/kg BB-Nicotinamide 100 BB (STZ-NA) Intraperitonial routes induced DM rat. STZ-NA triggers significantly influences protein. High blood levels give different activity due effects agent.